All of the problems you list seem harder with repeated within-person trials.
I found the gotcha: envoid has two other mechanisms of action. Someone pointed this out to me on my previous nitric oxide post, but it didn't quite sink in till I did more reading.
Yep that's my main contender for the better formulations referred to in the intro. .
I don't think the original comment was a troll, but I also don't think it was a helpful contribution on this post. OP specifically framed the post as their own experience, not a universal cure. Comments explaining why it won't work for a specific person aren't relevant.
I think that's their guess but they don't directly check here.
I also suspect that it doesn't matter very much.
I'd love to test this. The device you linked works via the mouth, and we'd need something that works via the nose. From a quick google it does look like it's the same test, so we'd just need a nasal adaptor.
Other options:
I'm also going to try to talk my asthma specialist into letting me use their oral machine to test my nose under multiple circumstances, but it seems unlikely she'll go for it.
obvious question: so why didn't evolution do that? Ancestral environment didn't have nearly this disease (or pollution) load. This doesn't mean I'm right but it means I'm discounting that specific evolutionary argument.
although NO is also an immune system signal molecule, so the average does matter.
Check my math: how does Enovid compare to to humming?
Nitric Oxide is an antimicrobial and immune booster. Normal nasal nitric oxide is 0.14ppm for women and 0.18ppm for men (sinus levels are 100x higher). journals.sagepub.com/doi/pdf/10.117…
Enovid is a nasal spray that produces NO. I had the damndest time quantifying Enovid, but this trial registration says 0.11ppm NO/hour. They deliver every 8h and I think that dose is amortized, so the true dose is 0.88. But maybe it's more complicated. I've got an email out to the PI but am not hopeful about a response clinicaltrials.gov/study/NCT05109…
so Enovid increases nasal NO levels somewhere between 75% and 600% compared to baseline- not shabby. Except humming increases nasal NO levels by 1500-2000%. atsjournals.org/doi/pdf/10.116….
Enovid stings and humming doesn't, so it seems like Enovid should have the larger dose. But the spray doesn't contain NO itself, but compounds that react to form NO. Maybe that's where the sting comes from? Cystic fibrosis and burn patients are sometimes given stratospheric levels of NO for hours or days; if the burn from Envoid came from the NO itself than those patients would be in agony.
I'm not finding any data on humming and respiratory infections. Google scholar gives me information on CF and COPD, @Elicit brought me a bunch of studies about honey.
With better keywords google scholar to bring me a bunch of descriptions of yogic breathing with no empirical backing.
There are some very circumstantial studies on illness in mouth breathers vs. nasal, but that design has too many confounders for me to take seriously.
Where I'm most likely wrong:
I curated this post because
Brandon Sanderson is a bestselling fantasy author. Despite mostly working with traditional publishers, there is a 50-60 person company formed around his writing[1]. This podcast talks about how the company was formed.
Things I liked about this podcast:
The only non-Sanderson content I found was a picture book from his staff artist.
https://www.modestneeds.org/ will give one time cash infusions to people with capital intensive problems (like moving costs, or keeping a vehicle). I haven't looked into them in a while; a few years ago there was a requirement that the cash infusion would get recipients on a stable track, I think that might be looser now.