Some things I learned while researching air purifiers for my house, to reduce COVID risk during jam nights.
[1] For large rooms, another concern is getting air to circulate properly.
[2] One might worry that the 20% of particles that pass through MERV filters will be more likely to pass through again, which would put a ceiling on the achievable purification. But in practice, you can get to the air quality of a low-grade cleanroom with enough MERV 13 filtration, even if the filters are a few months old. Also, MERV filters get a slight efficiency boost from the slower airflow of a PC fan CR box.
[3] Most commercially available air purifiers have even worse CADR/$ or noise than the Wirecutter picks.
[4] The Wirecutter top pick was tested at 110 CFM on medium; the CleanAirKits Luggable XL was tested at 323 CFM at around the same noise level (not sure of exact values as measurements differ, but the Luggable is likely quieter) and footprint with slightly higher power usage.
Luckily, that's probably not an issue for PC fan based purifiers. Box fans in CR boxes are running way out of spec with increased load and lower airflow both increasing temperatures, whereas PC fans run under basically the same conditions they're designed for.