I am not sure how to proceed with my alignment work in the absence of a quorum of people willing to upvote the most valuable and important parts of my research agenda.
I think the answer is: don't.
Going by the feedback, your research agenda seems valuable and important to you, but not to the LessWrong community. So there is no reason why LessWrong should host your Sequence. (I would tell you to put it on Substack instead, but you already did.)
Can we add posts with negative karma to a Sequence? I'm working on a Sequence for my alignment research agenda, and the most valuable content in the sequence is all currently underwater. I get that LessWrong wants the community to have veto authority over people creating Sequences and adding controversial posts to them, but I am not sure how to proceed with my alignment work in the absence of a quorum of people willing to upvote the most valuable and important parts of my research agenda.