I saw the idea a few times (including on LW), and support it, to do/allow human trials for CoronaVirus vaccine without animal trials.
My question is - how dangerous is it for a person to volunteer to test a vaccine (both with and without animal trials)?
How dangerous is it compared to getting the virus itself?
How should someone decide whether to volunteer?
I think an answer is mainly how "fat" the tail is, which you addressed.
i am wondering though, how much of the risks to animals in animal trials apply to humans. not because of difference in biology, but whether we can know how much we don't know about a vaccine before we give it, and only give the least uncertain to humans (cause i assume we're being less careful on animals). i guess we can't know much and my prior on testing vaccines was "dangerous on average, with really fat tail"