Isn’t this a really small amount, like a single raisin has this much free glucose in it right? Why not just microdose raisins? How does this create a signal against normal blood glucose variation? Your gut should be releasing a lot more glucose from just the oats. Do you have a metabolic disorder? I guess I’m trying to reason out about why your body isn’t already supplying the glucose to your brain in the first place from current digestion, and why would glucose microdosing get around this.
It's possible I have a metabolic disorder that wouldn't be detected by regular blood tests. And yes the amount of glucose is absolutely tiny. I also bought a blood glucose meter. It doesn't show elevated values at all from supplementing glucose. When eating it does increase measurably in line with what is normal. I do have sleep apnea which might do weird stuff, like give you diabetes. I do have a CPAP though maybe there is still some effect from that.
I don't quite understand why it works. But it seems really strong of an effect. Once I increased the amount of MPH I took, then I took 0.6g of glucose, and it suddenly made me feel a pressure in my heart. The effect of the MPH was now too much. Something was throttling the effect of MPH before taking the glucose. And somehow taking the glucose stopped the throttling. This happened in less that 10 minutes. Probably less than 5.
Have you tried double-blinding yourself, Gwern-style? (I. e., prepare a box with glucose capsules and a box with some placebo (empty capsules + close your eyes when taking them out of the box?); at the start of the day, pick the box to take capsules from at random; at the end of the day, try to guess whether it was the placebo box; then check; repeat for several days.)
Observation
I take 60mg methylphenidate daily. Despite this, I often become exhausted and need to nap.
Taking small amounts of pure glucose (150-300mg every 20-60 minutes) eliminates this fatigue. This works even when I already eat carbohydrates. E.g. 120g of oats in the morning don't prevent the exhaustion.
Proposed Mechanism
Facts:
Hypothesis-1: The brain throttles cognitive effort when too much glutamate has accumulated.
Facts:
Hypothesis-2: Sustained stimulant use depletes astrocyte glycogen faster than it can be replenished.
Hypothesis-3: Elevated blood glucose helps glycogen synthesis, thereby maintaining clearance capacity.
If these hypotheses hold, supplementing small amounts of pure glucose while working on stims, should reduce fatigue by supporting astrocyte glycogen replenishment, which in turn increased how much glutamate can be cleared. Possibly this has an effect even when not on stims.
Protocol
150-300mg glucose every 20-60 minutes, taken as a capsule.