Jetlag, Nausea, and Diarrhea are Largely Optional

Other things that are optional:

Ads and paywalls are only optional if you're ok freeloading.

(I can see arguments for either blocking ads or bypassing paywalls, but not both with the same views.)

Thanks for reminding me. I now have subscriptions to Wirecutter and some things on Patreon/Substack but wish there were a better way to incentivize good content than subscribing to entire news sites, especially when 99% of articles on many news sites are vacuous.

[-]Alex Vermillion4y10

This is true, but I'll expand the discussion to somewhere more niche than I normally see it go: consider getting a tool like ublock origin and using custom filters to remove distractions.

When I see other people use the internet, it boggles me how many parts of web pages are useless to them but allowed to stay for no reason. I take out things like cookie warnings I've seen countless times, the very distracting sidebar on StackOverflow^[1], or anything else that has a risk of dragging me off course.

I mention this because I notice people usually associate these programs only with ads, when a philosophically anti-adblock person could get a hell of a lot of benefit out of removing annoyances instead, while never doing anything they think would hurt the webpage's wallet.

There's rarely a time I don't want the answer to some pedantic and obtuse question about math, tabletop games, or whatever else, but the time is equally rare that I am on SO and am not, for example, trying to solve a bug or something. ↩︎

[-]RyanCarey4y80

Many people don't realize how effective migraine treatments are. High-dose aspirin, tryptans, and preventers all work really well, and can often reduce migraine severity by 50-90%.

Also, most don't yet realise how effective semaglutide is for weight loss, due to the fact that weight loss drugs have generally been much less effective, or had much worse side-effects previously.

Balding treatments (finasteride and topical minoxodil) are also pretty good for a lot of people.

[-]moridinamael4y30

Many people don't even realize that they have migraines, and treat their recurring headaches with NSAIDs or acetaminophen, instead of the vastly more effective triptans. And as you say, few are aware of the new and miraculous CGRP inhibitor class of migraine preventative drugs.

[-]CronoDAS4y20

Bypass paywalls doesn't work on the mobile browser.

[-]Adam Selker4y10

How do you avoid bug bites?

[-]gilch2y20

Permethrin-treated clothing is effective against bugs like ticks and mosquitoes, although for the flying kind, you probably still want some DEET for any exposed skin. Don't bother with DEET-treated bracelets (yes, that's a thing); the short range of effectiveness means they will only protect your wrists.

[-]Thomas Kwa4y10

There are lots of bug repellents. Being from a dry climate I have little experience with this, but Wirecutter recommends picaridin-based repellents, and I expect a tiny bottle of 100% DEET to be practical enough to carry around everywhere.

[-]gilch2y20

While "100%" DEET products were available last I checked, more than 50% does not improve duration or effectiveness. It's also a solvent that can dissolve (or permanently soften) plastics, as well as synthetic fibers used for clothing. And it makes sunscreen much less effective. The recommendation there is to allow the skin to absorb the sunscreen for 30 minutes before applying any DEET, so combination products are probably a bad idea.

[-]Thomas Kwa2y20

Why would applying half the amount of 100% DEET be worse than the full amount of 50% DEET?

[-]gilch2y20

And how do you apply 50% of the 100% formula? Apply it to your left side only? I suspect it would be difficult to limit the dose and still cover all your exposed skin; it can only be spread so thin before it's absorbed. Beyond a certain concentration, you would have to dilute it first.

https://en.wikipedia.org/wiki/DEET#Concentrations claims that Canada banned concentrations over 30% since 2002 due to health risks. More than 30% doesn't seem to be any more effective, but does last longer, at least up to about 50%, which might still be worth the risk in areas with malaria. More than that doesn't seem to help, but is more likely to have side effects or damage your clothes.

https://wwwnc.cdc.gov/travel/yellowbook/2024/environmental-hazards-risks/mosquitoes-ticks-and-other-arthropods (a reasonably reputable government source) claims

Studies suggest that DEET efficacy tends to peak at a concentration of ≈50%, and that concentrations above that do not offer a marked increase in protection time against mosquitoes.

Unfortunately, it does not cite which studies, but it's a good reason to assume they exist, if we want to go digging.

[-]Mitisaks3y130

I am concerned that by removing pills from their original packaging (blister or pill box), you are losing track of the expiry date of the medications, putting you at risk of sub-optimal drug effects. Perhaps, also label the date by which you replace the meds?
Other random pointers (I am a medical doctor):
- I highly recommend Ondansetron. It should be easy to request any doctor you see to write you a prescription for one. It works like a charm for any nausea, hangover, migraine, seasickness, stomach bug, heartburn, or anxiety, etc.
- Acetaminophen(Tylenol) or Paracetamol, based on where you are located, is a must for fevers.
- If you are prone to allergies, carrying an antihistamine, such as cetirizine or levocetirizine, helps a lot.
- Saline eye drops for dryness (long hours at the computer), or random foreign bodies (specks)
- Add something for heartburn/acidity. This can be ranitidine or omeprazole(Id avoid this but for extreme cases) . This works when you eat something spicy or too much of something leading to discomfort. Look at this as a one-step above your regular tums.
- Personal fav pill organizer

Should I write a detailed post or link a detailed google doc about OTCs?

[-]jefftk4y*120

The idea here seems to be something like:

Everyone knows you can handle jetlag, nausea, and diarrhea with pills.
People don't actually do this because keeping the pills around is inconvenient.
Maintaining a pill organizer makes it convenient.

My guess is that #1 is actually not the case, and the main reasons people do not treat these as optional is that they don't know these can be handled with pills, they don't know how to handle these with pills, or handling these with pills doesn't actually work well for them.

[-]MichaelDickens4y60

I "know" that nausea can be handled with a pill, but it had never occurred to me to carry around a couple anti-nausea pills.

[-]Alex Vermillion4y10

How often do you suffer from nausea? I'll admit to the fact that I carry around none of these because I never need them (except for the fact that I keep a bottle of melatonin on my bed).

[-]MichaelDickens4y30

I get motion sickness easily, but I don't often suffer from nausea because I avoid doing things that make me motion sick (e.g., reading in the car). If I took anti-nausea pills, I could do those things more.

[-]Said Achmiz4y60

Yeah, I definitely didn’t know a good chunk of the stuff listed in the OP (and in fact suspect that at least some of it is not true and/or comes with significant drawbacks not listed).

[-]Morpheus4y50

Personally, I found a weekly pill organizer very helpful because I could tell whether I had already taken my meds or not.

[-]Austin Chen4y50

Just wanted to say I've purchased a pill organizer based on your recommendation, and plan on checking out your anti-diarrhea and anti-nausea picks! I'll also probably slot in Tums for acid reflux.

[-]angelinahli4y40

Here's a Share-a-cart link to grab all of the 6 basic pills + pill organizer on Amazon for ~$57. (Click on the link, click "Send all to cart", and then "Add to cart" at the bottom).

I did very minimal research for this and mostly just clicked on the first fine-seeming product per item on the list, and did not check whether things were vegan, the best possible product in each category, etc. Commenting mostly to encourage people to use services like Share-a-cart when publishing shopping lists to make it super easy for people to buy things you recommend.

[-]Big Tony4y30

If there's something wrong that's causing recurring issues (e.g. diarrhea), then taking medication to prevent diarrhea is fixing the symptom and obscuring the cause. It obscures any signal that might lead to identification of the cause while exposing you to the medication's side-effects.

For example, someone with lactose intolerance (but who doesn't know it yet) goes from "I notice that when I eat x, I get diarrhea for the next week" without medication, to "I eat what I want and experience no symptoms, but I do notice I have been feeling more tired and low in energy over the past few months" with medication.

[-]Cervera4y10

How could one end up taking the correct medication without knowing first that they're lactose intolerant?

I don't see how that could happen. To end up taking lactose pills you need to know there is something wrong with your lactase tolerance in particular.

[-]gilch2y*20

I'm concerned about taking pills for jet lag, since sleep aids that are perfectly legal might not be at your destination. Even fairly tame ones like melatonin are illegal in some areas.

[-]chasmani4y2-2

There are extra costs here that aren’t being included. There’s a cost to maintaining the pill box - perhaps you consider that small but it’s extra admin and we’re already drowning in admin. There’s a cost to my self identity of being a person who carries around pills like this (don’t mean to disparage it, just not for me). There’s also potentially hidden costs of not getting ill occasionally, both mentally and physically.

[-]freemany3y10

This is amazing, thank you!

[-]Jacob Pfau4y10

I once had a multiple day hospitalization following use of modafinil (to prevent jetlag) during a flight -- checkups found no clear cause. This is obviously N=1, but still makes me wonder if there's some adverse interaction between modafinil and pressure changes. Would be interested if anyone has had similar experiences and/or knows of a relevant mechanism.

[-]RedMan4y10

What were the symptoms that led you to go to the hospital, and what did they observe there that convinced them to have you stay after the initial exam?

[-]Jacob Pfau4y10

Sleeping 22 hours a day for 2-3 days pre-admission and fever. I think the presumption was those sorts of symptoms merit careful investigation. Don't remember if there were any particular test results that were remarkable. IIRC there weren't.

Seeing as the modafinil was not prescription, and I've never heard of similar symptoms from others, it's quite plausible my pills were just contaminated with some other substance. Still should probably update against taking modafinil without prescription, since this contamination risk is just as important as side-effect symptoms.

[-]RedMan4y10

So you procured study drugs from an illicit source, took them, felt your body temp rise, stopped taking them, spent the next few days sleeping like crazy, and presented at the hospital?

Did they do a tox screen (meth and similar stimulants?)

I posted on another thread a while ago, according to dancesafe, counterfeit modafinil that's actually low dose methamphetamine was being marketed in Berkeley. I'd expect this to be common, because the following reasoning is a 'flash of inspiration' I'd expect a drug dealer to have...

Nerds have money -> nerds want study drugs -> most study drugs are stimulants -> pill press is cheap -> meth is widely available -> dilute the meth doses you'd usually sell to tweakers, put in pill press to look like study drug, sell to nerds.

Brilliant plan right?

[-]Jacob Pfau4y10

That certainly sounds scary, but seems unlikely in my case. No tox screen, but also did not buy locally in Berkeley, and had previously used the pills without problem.

LESSWRONG
LW

LESSWRONG
LW

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Jetlag, Nausea, and Diarrhea are Largely Optional

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