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Elizabeth Van Nostrand spent literal decades seeing doctors about digestive problems that made her life miserable. She tried everything and nothing worked, until one day a doctor prescribed 5 different random supplements without thinking too hard about it and one of them miraculously cured her. This has led her to believe that sometimes you need to optimize for luck rather than scientific knowledge when it comes to medicine.
A look at how we can get caught up in the details and lose sight of the bigger picture. By repeatedly asking "what are we really trying to accomplish here?", we can step back and refocus on what's truly important, whether in our careers, health, or life overall.
Sometimes your brilliant, hyperanalytical friends can accidentally crush your fragile new ideas before they have a chance to develop. Elizabeth shares a strategy she uses to get them to chill out and vibe on new ideas for a bit before dissecting them.
When tackling difficult, open-ended research questions, it's easy to get stuck. In addition to vices like openmindedness and self-criticality, Holden recommends "vices" like laziness, impatience, hubris and self-preservation as antidotes. This post explores the techniques that have worked well for him.
Holden shares his step-by-step process for forming opinions on a topic, developing and refining hypotheses, and ultimately arriving at a nuanced view - all while focusing on writing rather than just passively consuming information.
Limerence (aka "falling in love") wrecks havoc on your rationality. Evolution gave us capacity for reason, but also it built in massive hardcoded overrides for situations where no fuck you your brain is not for building rocketships and new abstract theories, your brain is for producing children and entangling yourself with a partner long enough to raise them.
Forget this at your peril.
Do you pass the "onion test" for honesty? If people get to know you better over time, do they find out new things, but not be shocked by the *types* of information that were hidden? A framework for thinking about personal (and institutional) honesty.